2E

2E or II-E may refer to:
 * 2nd meridian east, a longitude coordinate
 * Apple IIe, a 1983 model in the Apple II series of personal computers
 * Aptera 2e, the 2009 and first model in the Aptera 2 Series by Aptera Motors
 * Oflag II-E, a prisoner of war camp in Germany
 * 2nd arrondissement of Paris
 * Transcription Factor II E
 * Twice exceptional, an individual with special needs who is also gifted.
 * A reference to data collected by the Einstein Observatory (version 2)
 * YoRHa No. 2 Type E, the actual designation of YoRHa No. 2 Type B in Nier: Automata
 * Advanced Dungeons & Dragons 2nd Edition, a version of the Dungeons & Dragons role-playing game that debuted in 1989.
 * Pathfinder Second Edition, a version of the Pathfinder role playing game that debuted in 2019.