2U

2U or 2-U may refer to:


 * 2U (album), a 2006 album by Keshia Chante, and its title track
 * 2U (company), an educational technology company
 * "2U" (David Guetta song), a 2017 song by David Guetta featuring Justin Bieber
 * "2U" (Kang Daniel song), a 2020 song by Kang Daniel
 * 2&U, a planned high-rise office building in Seattle, Washington, USA
 * Sun d'Or International Airlines' IATA code
 * 2U, a rack unit measurement
 * The acronym for the second (2nd) catalog of Uhuru x-ray sources