3,5,7-Trioxododecanoyl-CoA synthase

3,5,7-Trioxododecanoyl-CoA synthase (, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming). This enzyme catalyses the following chemical reaction


 * 3 malonyl-CoA + hexanoyl-CoA $$\rightleftharpoons$$ 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa.