3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction


 * GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R $$\rightleftharpoons$$ GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R, whereas its 3 products are GDP, beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-, and glucosaminyl-R.

This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.

Nomenclature
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase. Other names in common use include:


 * (Lea)-dependent (alpha-3/4)-fucosyltransferase,
 * alpha(1,3/1,4) fucosyltransferase III,
 * alpha-(1->4)-L-fucosyltransferase,
 * alpha-4-L-fucosyltransferase,
 * beta-acetylglucosaminylsaccharide fucosyltransferase,
 * FucT-II,
 * Lewis alpha-(1->3/4)-fucosyltransferase,
 * Lewis blood group alpha-(1->3/4)-fucosyltransferase,
 * Lewis(Le) blood group gene-dependent,
 * alpha-(1->3/4)-L-fucosyltransferase,
 * blood group Lewis alpha-4-fucosyltransferase,
 * blood-group substance Lea-dependent fucosyltransferase,
 * guanosine diphosphofucose-beta-acetylglucosaminylsaccharide,
 * 4-alpha-L-fucosyltransferase,
 * guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase,
 * guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase,
 * 3-alpha-galactosyl-N-acetylglucosaminide,
 * 4-alpha-L-fucosyltransferase,
 * GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and 4I-alpha-L-fucosyltransferase.