3-chloro-D-alanine dehydrochlorinase

The enzyme 3-chloro- D -alanine dehydrochlorinase (EC 4.5.1.2) catalyzes the reaction


 * 3-chloro- D -alanine + H2O = pyruvate + chloride + NH3 (overall reaction)
 * (1a) 3-chloro- D -alanine = chloride + 2-aminoprop-2-enoate
 * (1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
 * (1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 3-chloro- D -alanine chloride-lyase (deaminating; pyruvate-forming). Other names in common use include β-chloro- D -alanine dehydrochlorinase, and 3-chloro- D -alanine chloride-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.