3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase

In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:


 * (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD+ + H2O $$\rightleftharpoons$$ (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H+

The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD+, and H2O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H+. This enzyme participates in bile acid biosynthesis.

Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:
 * cholestanetriol-26-al 26-dehydrogenase,
 * 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
 * trihydroxydeoxycoprostanal dehydrogenase,
 * THAL-NAD oxidoreductase,
 * 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
 * 26-oxidoreductase.