4-Fluoroselegiline

4-Fluoroselegiline or p-fluoro- L -deprenyl is a substituted amphetamine designer drug. Much like its parent compount, selegiline, it is a selective and irreversible inhibitor of monoamine oxidase B.

Pharmacodynamics
4-Fluoroselegiline has a similar pharmacological profile to its parent compound, selegiline.

A radiolabelled derivative incorporating 18F is used to study MAO-B inhibition in both in vivo and in vitro experiments.

Pharmacokinetics
p-Fluoro- L -deprenyl is metabolized to p-fluoro- L -methamphetamine and p-fluoro- L -amphetamine, both of which are active. The levels of substituted amphetamine metabolites in the brain is three times higher following 4-fluoroselegiline administration compared to an equivalent dose of selegiline.