4-Hydroxycoumarin synthase

4-hydroxycoumarin synthase (, BIS2, BIS3) is an enzyme with systematic name malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase. This enzyme catalyses the following chemical reaction


 * malonyl-CoA + 2-hydroxybenzoyl-CoA $$\rightleftharpoons$$ 2 CoA + 4-hydroxycoumarin + CO2

This polyketide synthase can also accept benzoyl-CoA as substrate.