4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction


 * GDP-beta-L-fucose + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R $$\rightleftharpoons$$ GDP + 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl- R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R. Its 3 products are GDP, 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-, and R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase. Other names in common use include:
 * Lewis-negative alpha-3-fucosyltransferase
 * plasma alpha-3-fucosyltransferase
 * guanosine diphosphofucose-glucoside alpha1→3-fucosyltransferase
 * galactoside 3-fucosyltransferase
 * GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
 * 3-L-fucosyltransferase
 * GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and
 * 3-L-fucosyltransferase

This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes, , and.