454 (disambiguation)

AD 454 was a year of the Julian calendar.

454 may also refer to:
 * 454 BC, a year of the pre-Julian Roman calendar
 * 454 Life Sciences, an American biotech company
 * .454 Casull, a handgun cartridge
 * 454, a model of the Chevrolet big-block engine
 * 454 Mathesis, a main-belt asteroid