5,7-Dihydroxy-6-methoxy-2-(4-phenoxyphenyl)chromen-4-one

5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one (DMPC) is a derivative of oroxylin A. It has memory improving effects and can reduce ADHD-like behavior.

Mechanism of action
As a derivative of oroxylin A, it has similar activity; in rats, DMPC has been shown to block the reuptake of dopamine similarly to methylphenidate, however it does not act at the norepinephrine transporter. This has resulted in attenuated ADHD-like behavior, but unlike methylphenidate and other ADHD medication, it did not display addictive properties. Which could make it useful as a non-addictive ADHD drugs, as most currently used ADHD stimulants have addictive properties.

DMPC also possesses memory improving properties, it is able to attenuate memory impairment induced by scopolamine and MK-801. It also had memory-enhancing effects if administered alone.

DMPC is able to block the chloride influx induced by muscimol at GABAA receptors, suggesting that it is a GABAA antagonist or negative modulator.