5E

5E or 5-E can refer to:


 * 5°E, or 5th meridian east, a longitude coordinate
 * 5e, a type of Category 5 cable
 * 5E, a learning cycle developed by Biological Sciences Curriculum Study.
 * Astra 5°E, a communications satellite
 * Dungeons & Dragons 5th edition, a fantasy tabletop role-playing game (RPG) released in 2014.
 * F-5E, a model of Northrop F-5 jet
 * Five Eyes, an espionage alliance between the US, UK, NZ, Canada, and Australia.
 * Tropical Depression Five-E (2008)
 * SGA Airlines (IATA airline code)
 * 5E, the production code for the 1978–79 Doctor Who serial The Power of Kroll