6-Methylapigenin

6-Methylapigenin is a naturally occurring flavonoid and a derivative of apigenin. It has activity at GABAA receptors as a positive modulator.

Natural occurrence
6-Methylapigenin can be found in multiple plants, such as Valeriana officinalis, Valeriana jatamansi, and Picea neoveitchii.

Biological activity
6-Methylapigenin binds to the GABAA receptor on the benzodiazepine binding site. This compound possesses anxiolytic effects. In a mouse model, it is also able to potentiate sleep induced by hesperidin, another flavonoid. However, since it does not have the chemical structure of benzodiazepines, it can therefore be classed as a nonbenzodiazepine.