A52

A52 may refer to:
 * Ubiquitin A-52 residue ribosomal protein fusion product 1, a human gene

Roads

 * A52 road (England), a road connecting Newcastle-under-Lyme and Mablethorpe
 * A52 motorway (France), a road connecting Aubagne and the A50
 * Bundesautobahn 52, a highway in Germany usually referred to as A52
 * A52 motorway (Italy), a ring road around Milan
 * A52 motorway (Switzerland), a road connecting Zumikon and Hinwil
 * Autovía A-52 Spain, highway connecting Benavente and O Porriño

Other

 * Samsung Galaxy A52, an Android smartphone
 * The A/52 audio codec, also known as AC-3 or Dolby Digital
 * One of the Encyclopaedia of Chess Openings codes for the Budapest Gambit in chess
 * Action 52, a video game developed by Active Enterprises