A74

A74 or A-74 may refer to:


 * A74 road, a major road in the United Kingdom
 * A74(M) and M74 motorways, another road in the United Kingdom that largely replaced the original A74
 * Benoni Defense, in the Encyclopaedia of Chess Openings
 * HLA-A74, an HLA-A serotype
 * Iceberg A-74, an iceberg calved from the Antarctic Brunt Ice Shelf in February 2021