A81

A81 or A-81 may refer to:
 * A81 Music Recording artist A81 Los Angeles California 1988-Present
 * A81 motorway (France)
 * A81 road (Scotland)
 * A81 motorway (Germany)
 * Dutch Defence, in the Encyclopaedia of Chess Openings
 * RFA Brambleleaf (A81), a Royal Fleet Auxiliary Tanker
 * Iceberg A-81, iceberg that calved from the Brunt Ice Shelf in January 2023