ACSC

ACSC may refer to:


 * Advanced Casino Systems Corporation, a product group of Bally Technologies
 * Air Command and Staff College, Montgomery, Alabama
 * Alternating Closed and Semi-Closed rebreather, a special type rebreather for diving
 * Ambulatory care sensitive conditions, a category of illnesses or health conditions
 * Anderson Community School Corporation, Anderson, Indiana
 * Asheville City SC, a National Premier Soccer League club based in Asheville, North Carolina
 * Australian Command and Staff College, Weston Creek, Canberra
 * Australian Cyber Security Centre
 * Automobile Club of Southern California