ADP-ribosylhydrolase 1

(ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-Nω-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase, is an enzyme that in humans is encoded by the ADPRH gene. This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates. The chemical reactions can formally be described as follows:


 * Nω-(ADP- D -ribosyl)-L-arginyl-[protein] + H2O $$\rightleftharpoons$$ ADP- D -ribose + L-arginyl-[protein]
 * In addition, the enzyme can reverse the ADP-ribosylation of free arginine:
 * Nω-(ADP- D -ribosyl)-L-arginine + H2O $$\rightleftharpoons$$ ADP- D -ribose + L-arginine