APFA

APFA may refer to:


 * American Professional Football Association, later the National Football League, a professional American football league that operated during 1920–1921
 * American Professional Football Association, later the Midwest Football League (1935–1940), a minor professional American football league
 * Association of Professional Financial Advisers, a trade association made up of financial advisers across the United Kingdom
 * Association of Professional Flight Attendants, a transportation trade union in the United States
 * Association for the Protection of Fur-Bearing Animals, an animal welfare organization based in Canada