Acetyl-CoA hydrolase

The enzyme acetyl-CoA hydrolase (EC 3.1.2.1) catalyzes the reaction



acetyl-CoA + H2O $$\rightleftharpoons$$ CoA + acetate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is CoA thiol esterase. This enzyme participates in pyruvate metabolism.

Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.