Acyl-CoA hydrolase

The enzyme acyl-CoA hydrolase (EC 3.1.2.20) catalyzes the reaction


 * acyl-CoA + H2O $$\rightleftharpoons$$ CoA + a carboxylate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.

Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.