Afadin

Afadin is a protein that in humans is encoded by the AFDN gene.

Function
Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM]

Interactions
Afadin has been shown to interact with:


 * BCR gene,
 * EPHB3,
 * F11 receptor,
 * HRAS and
 * LMO2,
 * PVRL1,
 * PVRL3,
 * Profilin 1,
 * RAP1A,
 * RAP1GAP,
 * SORBS1,
 * SSX2IP,
 * Tight junction protein 1, and
 * USP9X.