Alpha-actinin-1

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Function
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures. Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Interactions
Alpha-actinin-1 has been shown to interact with:
 * CDK5R1,
 * CDK5R2,
 * Collagen, type XVII, alpha 1,
 * GIPC1,
 * PDLIM1,
 * Protein kinase N1,
 * SSX2IP, and
 * Zyxin.
 * PTPRT (PTPrho)