Alpha 1

Alpha 1 or Alpha-1 may refer to:
 * Alpha-1 adrenergic receptor, a G protein-coupled receptor
 * Alpha-1 antitrypsin, a protein
 * Alpha-1 antitrypsin deficiency, a genetic disorder
 * Alpha-1-fetoprotein or Alpha-fetoprotein, a protein
 * Alpha-One, a fictional spacecraft in Buzz Lightyear of Star Command: The Adventure Begins
 * Alpha 1 (Robert Silverberg anthology), a 1970 book
 * Alpha-1 Wrestling, a professional wrestling promotion