Antonio Smith

Antonio Smith may refer to:


 * Antonio Smith (artist) (1832–1877), Chilean landscape painter and caricaturist
 * Antonio Smith (athlete) (born 1967), Venezuelan hurdler
 * Antonio Smith (defensive end) (born 1981), American football defensive end
 * Antonio Smith (cornerback) (born 1984), American football cornerback
 * Antonio Arnelo Smith, involved in an alleged police brutality incident in Valdosta, Georgia, in 2020
 * Antonio Smith (basketball), university basketball player from Flint, Michigan