Asian Academy Creative Award for Best Actress in a Leading Role

This is a list of the winners of the Asian Academy Creative Award for Best Actress in a Leading Role since its institution in 2018. The award is presented to the best leading actress performance in a television series or film. Apart from the main award, the category is also awarded regionally in seventeen participating nations.

Winners
The following table display the winners of the award.

Regional winners
The following table display the winners of the regional award, sorted by the participating nations. Reference by year:
 * 2018:
 * 2019:
 * 2020:
 * 2021:
 * 2022:
 * 2023: