Axial osteosclerosis

Axial osteosclerosis, also known as osteomesopyknosis, is a bone disorder characterized by abnormal bone hardening of the bone. It is generally limited to the axial spine, pelvis and proximal part of the long bones, which is why it is profoundly distinct in comparison to other bone disorders. Osteomesopyknosis is inherited in an autosomal dominant manner but the genetic cause has not yet been identified.

Population estimation
Fewer than 1000 people have this bone disorder in the United States.

Symptoms
This bone disorder can begin to appear in the first years of life, as well as in adulthood. It may present with thoracic pain.