B59

B59 or B-59 may refer to:


 * B-59 military hardware:
 * Boeing XB-59, American aircraft model
 * Soviet submarine B-59, a submarine
 * B59:
 * European highways:
 * Bundesstraße 59, in the German Bundesstraße system
 * Eisenstädter Straße in the Austrian Landesstraße system
 * Volvo B59 Swedish-market bus chassis
 * HLA-B59, serotype re Human Leucocyte Antigen
 * B59, chess variation arising from 5...Nc6 in Sicilian Defence
 * Barnard 59, AKA Pipe Nebula