BRCT domain

BRCA1 C Terminus (BRCT) domain  is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.

Examples
Human proteins containing this domain include:


 * BARD1; BRCA1
 * CTDP1; TDT or DNTT
 * ECT2
 * LIG4
 * MCPH1; MDC1
 * NBN
 * PARP1; PARP4; PAXIP1; PES1
 * REV1; RFC1; TOPBP1; TP53BP1; XRCC1