Benzoxepin

Benzoxepin is an oxygen-containing bicyclic molecule consisting of an oxepin ring and a benzene ring. There are three isomers, varying in where the oxygen is positioned in the oxepin heterocycle relative where the benzene is fused to it.

Natural occurrence
1-Benzoxepin, with the oxygen closest to the benzene, is found in the skeleton of several fungal metabolites.

2-Benzoxepin skeletons are likewise found in fungal metabolites.



3-Benzoxepin, with the oxygen furthest from the benzene, is the core of natural products such as perilloxin from Perilla frutescens (variant Acuta) and tenual and tenucarb from Asphodeline tenuior.