Big Branch

Big Branch is the name for many rivers and streams. If can also refer to:


 * Big Branch (Middle Fork Salt River tributary), a stream in Missouri
 * Big Branch (Skull Lick Creek tributary), a stream in Missouri
 * Big Branch (Haw River tributary), a stream in Alamance County, North Carolina
 * Big Branch (Lanes Creek tributary), a stream in Anson County, North Carolina
 * Big Branch (Crabtree Creek tributary), a stream in Wake County, North Carolina
 * Big Branch Marsh National Wildlife Refuge
 * Upper Big Branch Mine disaster