Big Mouth season 6

The sixth season of Big Mouth was released on Netflix on October 28, 2022.

Main

 * Nick Kroll as Nick Birch, Maurice the Hormone Monster, Coach Steve Steve, Lola Skumpy and Marty's Lovebug
 * John Mulaney - Andrew Glouberman
 * Jessi Klein - Jessi Glaser
 * Jason Mantzoukas as Jay Bilzerian and Guy Bilzerian
 * Ayo Edebiri as Missy Foreman-Greenwald
 * Fred Armisen as Elliot Birch
 * Maya Rudolph as Connie the Hormone Monstress, Diane Birch
 * Jordan Peele as Duke Ellington and Cyrus Foreman-Greenwald

Recurring
• Andrew Rannells as Matthew MacDell

• Ali Wong as Ali

• Brian Tyree Henry as Elijah

• Thandiwe Newton as Mona

• Joe Wengert as Caleb, Lump Humpman and Joe

• Gil Ozeri as Gil

• June Diane Raphael as Devin LeSeven

• Jak Knight as DeVon

• Richard Kind as Marty Glouberman

• Paula Pell as Barbara Glouberman

• Seth Morris as Greg Glaser

• Jenny Slate as Caitlin Grafton

• Chloe Fineman as Leah Birch and Delilah

• Jon Daly as Judd Birch and Rodney

• Nathan Fillion as Himself

• Chris O’Dowd as Flanny O’Lympic

• Kristen Schaal as Bernadette "Bernie" Sanders

• Fran Gillespie as Samira

• Peter Capaldi as Seamus MacGregor

• Cole Escola as Montel

Guest
• Heather Lawless as Jenna Bilzerian

• Maria Bamford as Nancy

• Brandon Kyle Goodman as God's Boyfriend and Elijah's Uncles

• Annaleigh Ashford as The Rice Purity Test

• Amber Ruffin as Auntie Amber

• Mark Duplass and Paul Scheer as Val and Kurt Bilzerian

• Gina Rodriguez as Gina Alvarez

• Ira Glass as Himself

• Rosa Salazar as Miss Benitez

• Natasha Lyonne as Suzette

• Jeff Goldblum as The Apple Brooch

• Gary Cole as Edward MacDell

• Julie White as Kimberly MacDell

• Kristen Wiig as Jessi's Vagina and Beatrice

• Steve-O as Himself (in live-action)

• Tyler The Creator as Jesus

• Juliet Mills as Rita St. Swithens

• Ed Helms, Adam Levine, Matt Rogers are the members of the boy band, Bros 4 Life.