Big Sister

Big Sister may refer to:


 * An older sister, see birth order
 * Big Sister (brothel), an online brothel in Prague
 * "The Big Sister" (Dexter's Laboratory), an episode of Dexter's Laboratory
 * "Big Sister," a song by Elvis Costello and the Attractions from Trust
 * Big Sister's Island, one of the Sisters' Islands of Singapore
 * Big Sisters, part of the Big Brothers, Big Sisters program
 * Big Sister (radio), a United States radio soap opera
 * Big Sister, an enemy type in the game BioShock 2
 * Big Sis, a nickname for Secretary of Homeland Security Janet Napolitano
 * The Big Sister (film), a lost 1916 American drama silent film
 * Big Sister (foods), a brand of fruit cake and other baked goods in Australia