Big Snake

Big Snake may refer to:

People
 * Robin Big Snake (born 1984), Canadian former professional hockey player
 * Omoxesisixany, a chief of the Blackfoot Native American tribe
 * Big Snake (Ponca chief), a chief of the Ponca Native American tribe, and brother of the chief Standing Bear

Other:
 * Snake Creek (Susquehanna River), Pennsylvania, sometimes called Big Snake Creek