Biotin—(acetyl-CoA-carboxylase) ligase

In enzymology, a biotin—[acetyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reaction


 * ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] $$\rightleftharpoons$$ AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.

This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.

Nomenclature
The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include:
 * biotin-[acetyl-CoA carboxylase] synthetase,
 * biotin-[acetyl coenzyme A carboxylase] synthetase,
 * acetyl coenzyme A holocarboxylase synthetase,
 * acetyl CoA holocarboxylase synthetase,
 * biotin:apocarboxylase ligase,
 * biotin holoenzyme synthetase,
 * and HCS.