Brendan O'Brien

Brendan O'Brien may refer to:


 * Brendan O'Brien (bishop) (born 1943), Roman Catholic archbishop of Kingston, Ontario, Canada
 * Brendan O'Brien (cricketer) (born 1942), Irish former cricketer
 * Brendan O'Brien (journalist), senior Irish journalist on RTÉ's Prime Time current affairs programme
 * Brendan O'Brien (record producer) (born 1960), record producer, mixer, engineer, and musician
 * Brendan O'Brien (screenwriter), American screenwriter
 * Brendan O'Brien (voice actor) (1962–2023), actor and voice of many Crash Bandicoot characters