C4ISR

C4ISR may refer to:


 * the C4ISR concept of Command, Control, Communications, Computers, Intelligence, Surveillance and Reconnaissance, the U.S. term for C4ISTAR
 *  C4ISR Journal, a journal published by the Defense News Media Group
 * the C4ISR architectural framework (C4ISR AF), now known as Department of Defense Architecture Framework (DoDAF)