C53

C53 or C-53 may refer to:
 * ARM General Felipe Xicoténcatl, an Admirable-class minesweeper of the Mexican Navy
 * Caldwell 53, a lenticular galaxy
 * CDK5RAP3, a gene encoding CDK5 regulatory subunit-associated protein 3
 * Cervical cancer
 * Douglas C-53 Skytrooper, an American military aircraft
 * GER Class C53, a British tram engine class
 * HMCS Ontario (C53), a Minotaur-class light cruiser of the Royal Canadian Navy
 * JNR Class C53, a Japanese steam locomotive
 * Succession to the Throne Act, 2013, Bill C-53 of the Parliament of Canada