C54

C54 or C-54 may refer to:
 * ARM Cadete Agustín Melgar, an Admirable-class minesweeper of the Mexican Navy
 * Caldwell 54, an open cluster in the constellation Monoceros
 * Douglas C-54 Skymaster, an American transport aircraft
 * Giuoco Piano, a chess opening
 * JNR Class C54, a Japanese steam locomotive
 * Holidays with Pay (Sea) Convention, 1936 of the International Labour Organization
 * Uterine cancer