CAFC

CAFC may refer to:


 * Canadian Anti-Fraud Centre
 * Commission for Assistance to a Free Cuba, U.S. government organization established in 2003 to formulate policies for a democratic transition in Cuba
 * United States Court of Appeals for the Federal Circuit
 * The California Fire Safe Council
 * Cobblestone area forming cells in stem cell research
 * Corporate-average fuel consumption

Association football clubs:
 * Charlton Athletic F.C.
 * Crewe Alexandra F.C.
 * Cadbury Athletic F.C.
 * Carshalton Athletic F.C.
 * Consett A.F.C.
 * Cork Alberts F.C.
 * Cork Athletic F.C.
 * Crown Alexandra F.C.
 * Croydon Athletic F.C.
 * Curzon Ashton F.C.