CRKL

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.

Interactions
CRKL has been shown to interact with:


 * Abl gene,
 * BCAR1,
 * BCR gene,
 * CBLB,
 * CD117,
 * CD34,
 * Cbl gene,
 * Dock2,
 * EPOR,
 * GAB1,
 * GAB2,
 * INPP5D,
 * MAP4K1,
 * MAP4K5,
 * NEDD9,
 * PIK3R2,
 * Paxillin
 * RAPGEF1,
 * RICS,
 * STAT5A,
 * Syk, and
 * WAS.