California State Route 80

Three highways in the U.S. state of California have been signed as Route 80:
 * I-80 (CA).svgCalifornia 80.svg Interstate 80 in California, part of the Interstate Highway System, with the westernmost segment being a state highway.
 * Business Loop 80 (CA).svg Interstate 80 Business (Sacramento, California)
 * US 80 (1961 cutout).svg U.S. Route 80 in California (1928-1964)