Caloosahatchee

Caloosahatchee may refer to:


 * Caloosahatchee River, a river on the southwest Gulf Coast of Florida in the United States
 * Caloosahatchee culture, an archaeological culture on the Gulf coast of Southwest Florida that lasted from about 500 to 1750 CE
 * Caloosahatchee National Wildlife Refuge, part of the United States National Wildlife Refuge System
 * USS Caloosahatchee (AO-98), US Navy ship