Carboxy-lyases

Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.

Classification and nomenclature
Carboxy-lyases are categorized under EC number 4.1.1. Usually, they are named after the substrate whose decarboxylation they catalyze, for example pyruvate decarboxylase catalyzes the decarboxylation of pyruvate.

Examples

 * Aromatic-L-amino-acid decarboxylase
 * Glutamate decarboxylase
 * Histidine decarboxylase
 * Ornithine decarboxylase
 * Phosphoenolpyruvate carboxylase
 * Pyruvate decarboxylase
 * RuBisCO – the only carboxylase that leads to a net fixation of carbon dioxide
 * Uridine monophosphate synthetase
 * Uroporphyrinogen III decarboxylase
 * enoyl-CoA carboxylases/reductases (ECRs)