Case Closed season 21

The twenty-first season of the Case Closed anime was directed by Kōjin Ochi (until episode 666, and then 678–679) and Yasuichiro Yamamoto (since episode 667, except 678–679) and produced by TMS Entertainment and Yomiuri Telecasting Corporation. The series is based on Gosho Aoyama's Case Closed manga series. In Japan, the series is titled Detective Conan (名探偵コナン) but was changed due to legal issues with the title Detective Conan. The series focuses on the adventures of teenage detective Shinichi Kudo who was turned into a child by a poison called APTX 4869, but continues working as a detective under the alias Conan Edogawa.

The episodes use five pieces of theme music: two opening and three ending themes. The first opening theme is "Miss Mystery" by Breakerz up until episode 666. The second opening theme is lit. So Much Love With Your Tears (君の涙にこんなに恋してる) by Natsuiro starting from episode 667. The first ending theme is lit. "Compared With the Sadness, Today's Sunset Is More Beautiful" (悲しみほど　今日の夕陽きれいだね) by grram and is used up to episode 653. The second ending theme is "Overwrite" (オーバーライト), and by Breakerz between episode 654 and 666. The third ending theme is lit. "In Love With Love" (恋に恋して) by Mai Kuraki starting from episode 667.

The season aired between February 18, 2012, and December 15, 2012, on Nippon Television Network System in Japan. The season was later collected and released in nine DVD compilations by Shogakukan between February 22, 2013 and October 25, 2013, in Japan.