Castrillón (surname)

Castrillón is a Spanish surname. Notable people with the surname include:
 * Álvaro Mejía Castrillón (born 1967), Colombian road bicycle racer
 * Jaime Castrillón (born 1983), Colombian footballer
 * Manuel Fernández Castrillón (c. 1780–1836), major general in the Mexican army
 * Eduardo Crespo y García-Castrillón, 8th Count of Castillo Fiel (fl. 1963–1989), Spanish aristocrat
 * Darío Castrillón Hoyos (1929–2018), Colombian Cardinal of the Catholic Church