Cayuse

Cayuse may refer to:


 * Cayuse people, a people native to Oregon, United States
 * Cayuse language, an extinct language of the Cayuse people
 * Cayuse, Oregon, an unincorporated community in the United States
 * Cayuse horse, an archaic term for a feral or low-quality horse or pony
 * OH-6 "Cayuse", a military observation helicopter
 * Cayuse Five, five Cayuse who were hanged for murder