Charles Mayo

Charles Mayo may refer to:
 * Charles Horace Mayo (1865–1939), American physician
 * Charles Herbert Mayo (1845–1929), English antiquarian
 * Charles William Mayo (1898–1968), American surgeon
 * Charles Mayo (cricketer) (1903–1943), Canadian-born English cricketer
 * Charles Mayo (Anglo-Saxon scholar) (1767–1858), Rawlinson and Bosworth Professor of Anglo-Saxon at the University of Oxford
 * Charles Mayo (golfer), English professional golfer