Charles Shepard

Charles Shepard may refer to:


 * Charles Biddle Shepard (1808–1843), Congressional Representative from North Carolina
 * Charles C. Shepard (1914–1985), American microbiologist
 * Charles Upham Shepard (1804–1886), American mineralogist and chemist
 * Charles E. Shepard (1868-1932), American architect based in Kansas City with initials C.E.S., including for design of Charles S. Keith House.