Charles Sprague

Charles Sprague may refer to:


 * Charles Sprague (poet) (1791–1875), American poet
 * Charles James Sprague (1823–1903), American botanist
 * Charles Sprague Smith (1853–1910), activist and founder of the People's Institute during the Progressive era
 * Charles A. Sprague (1887–1969), Governor of Oregon, 1939–1943
 * Charles Ezra Sprague (1842–1912), American accountant
 * Charles F. Sprague (1857–1902), U.S. Representative from Massachusetts
 * Charlie Sprague (1864–1912), American baseball player